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Rating Action:

Moody's downgrades Eisai's ratings to A3; outlook stable

 The document has been translated in other languages

28 Jan 2011

JPY120 billion of rated debt affected

Tokyo, January 28, 2011 -- Moody's Japan K.K. has downgraded the issuer rating and senior unsecured ratings of Eisai Co., Ltd (Eisai) to A3 from A2. The outlook is stable.

The action concludes the review for possible downgrade initiated on October 22, 2010.

RATING RATIONALE

This rating action is based on Moody's view that Eisai's revenue will significantly decline and its overall credit metrics could remain weak for the A2 rating over the next few years, due to patent expirations and severe competition for its major products in the US market.

The action also reflects Moody's concern that it will be difficult for the company to fully offset the decline in revenue with its current in-patent products and the expected debut of new products.

The patent for its largest product Aricept -- for the treatment of Alzheimer's disease -- expired in November 2010 in the US, and Moody's expects a big decline in its sales in the US in the next few years. In the first half of FYE3/2011, sales of Aricept in the US accounted 25.7% of Eisai's total revenue.

Aricept 23 mg -- a new dosage of Aricept -- was approved by the Food and Drug Administration (FDA) in July 2010, and which has advantages over the existing Aricept 10mg and 5mg tablets -- should offer some promise. This new product could help treat moderate-to-severe Alzheimer's disease symptoms. But, the pace of market penetration by the new dosage seems slower than expected, and the speed of decline in the sales of existing Aricept 10mg and 5mg tablets will be much faster than the growth in sales of Aricept 23 mg. Moody's believes that sales of Aricept in the US could decline by more than 50% over the next year or two.

In addition, sales in the US of AcipHex -- a proton pump inhibitor which accounted 8.2% to total revenue for the first half of FYE3/2011 -- are stagnant due to extensive competition in the proton pump inhibitor therapeutic area, and even though the patent of AcipHex is still valid. To respond to such difficult market fundamentals, the company has developed an additional formulation of AcipHex -- named AcipHex ER -- and is now awaiting FDA approval. Moody's will focus on the progress of AcipHex ER and how it can offset the weak sales trend of AcipHex until the latter's patent expiration in May 2013.

On the other hand, Moody's expects that Eisai's earnings and cash flow will not decline in direct correlation to the expected sales drop for Aricept, and will instead be partially mitigated by these conditions:

1) Payments of co-promotion fees of Aricept to Pfizer will decrease in parallel with the sales decline.

2) The company maintains a leading market position in Japan as well as a strong position in the Alzheimer's disease therapeutic section in markets other than the US.

3) It has growing products, such as Humira, fully Human anti-TNF monoclonal antibody, Lyrica for peripheral neuropathic pain treatment, and MGI products, and maintains a promising pipeline, including Halaven of a new anticancer agent, which was approved by the FDA in November 2010 and is awaiting approvals in other regions.

These factors underpin the A3 rating and protected Eisai from a multi-notch downgrade, during the review.

The A3 rating also incorporates Eisai's prudent financial policy, which stipulates the use of free cash flow to balance shareholder returns, investment for growth, and debt payments. The company will maintain a healthy financial cushion over the medium term.

The stable rating outlook reflects the consideration that Eisai's strong efforts to mitigate the negative impact of the patent expirations of its major products will help stabilize earnings and its healthy financial cushion, supported by its prudent financial policy.

Significant new developments in its pipeline or product portfolio as well as significant improvement in its leverage could put upward pressure on the rating. The rating will also come upward pressure if revenue rebounds and regains momentum as a result of the timely launch of new products and the steady expansion of sales.

Moody's may also consider a positive rating action if adjusted debt/EBITDA declines below 2.0x and adjusted EBITA margin improves over 20% over the medium term, as the company maintains revenue growth.

Significant delay for the approval for its promising new products or further pressure on its earnings and cash flow due to the drastic unfavorable changes in its market fundamentals could put downward pressure on its rating. The rating may also come under pressure if revenue continues to decline after FYE3/2013 because of a stagnant product portfolio.

Moody's may also consider a negative rating action if adjusted debt/EBITDA rises above 3.0x and adjusted EBITA margin deteriorates below 15% over the medium term. Massive cash-based acquisitions, resulting in a significant deterioration of liquidity and its balance sheet, would increase downward pressure on its rating as well.

Moody's last rating action with respect to Eisai was taken on October 22, 2010 when the A2 rating was placed under review for possible downgrade.

The principal methodology used in this rating was Moody's "Global Pharmaceutical Industry," published on September 30, 2010, and available on www.moodys.co.jp.

Eisai Co., Ltd, headquartered in Tokyo, is a leading pharmaceuticals company in Japan.

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Information sources used to prepare the credit rating are the following: parties involved in the ratings, parties not involved in the ratings, public information, and confidential and proprietary Moody's information.

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Moody's Japan K.K. is a credit rating agency registered with the Japan Financial Services Agency and its registration number is FSA Commissioner (Ratings) No. 2. The Financial Services Agency has not imposed any supervisory measures on Moody's Japan K.K. in the past year.

Please see ratings tab on the issuer/entity page on the Moody's website for the last rating action and the rating history.

The date on which some Credit Ratings were first released goes back to a time before Moody's Credit Ratings were fully digitized and accurate data may not be available. Consequently, Moody's provides a date that it believes is the most reliable and accurate based on the information that is available to it. Please see the ratings disclosure page on the Moody's website for further information.

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Tokyo
Noriko Kosaka
Vice President - Senior Analyst
Corporate Finance Group
Moody's Japan K.K.
JOURNALISTS: (03) 5408-4110
SUBSCRIBERS: (03) 5408-4100

Tokyo
Shinsuke Tanimoto
Senior Vice President - Team Leader
Corporate Finance Group
Moody's Japan K.K.
JOURNALISTS: (03) 5408-4110
SUBSCRIBERS: (03) 5408-4100

Moody's Japan K.K.
Atago Green Hills Mori Tower 20fl
2-5-1 Atago, Minato-ku
Tokyo 105-6220
Japan
JOURNALISTS: (03) 5408-4110
SUBSCRIBERS: (03) 5408-4100

Moody's downgrades Eisai's ratings to A3; outlook stable
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